Paroles d’Experts : Le Covid Long

REFERENCES BIBLIOGRAPHIQUES :

CLINIQUE, SYMPTOMATOLOGIE

• Santé publique France. Enquête « COVID long – Affection post COVID-19, France métropolitaine », septembre – novembre 2022. Premiers résultats. 21/06/23.

  La Dépêche : DOSSIER. Covid long : en France, deux millions de personnes en souffrent. 30.7.2023

  HAS : Symptômes prolongés de la Covid-19 (dit Covid long) : la HAS actualise ses travaux . 21.4.2023

• Eric Yuk Fai Wan et all : Long-term effects of coronavirus disease 2019 on diabetes complications and mortality in people with diabetes: Two cohorts in the UK and Hong Kong. Diabetes, Metabolism and Obesity: 21 September 2023

• Viet-Thi Tran et coll : Course of post COVID-19 disease symptoms over time in the ComPaRe long COVID prospective e-cohort. Nature Communications volume 13,1812 (2022)

  Nisreen A. Alwan, Luke Johnson : Defining long COVID: Going back to the start. Med (N Y). 2021 May 14; 2(5): 501–504.

  Nabavi N. : Long covid: How to define it and how to manage it. BMJ. 2020;370

  NICE , National Institute for Health and Care Excellence (NICE); 2020 Dec 18COVID-19 rapid guideline: managing the long-term effects of COVID-19. London:.

  C.Huang et coll : 6-month consequences of covid-19 in patients dischargeg from hospital : a cohort study. The Lancet, vol 397, issue 10270, P220-232 ; January 16, 2012

  M. Bellan et coll : :Respiratory and Psychophysical Sequelae Among Patients With COVID-19 Four Months After Hospital Discharge. JAMA Netw Open. 2021;4(1):e2036142. doi:10.1001/jamanetworkopen.2020.36142

  K. Jacobson et coll : Patients With Uncomplicated Coronavirus Disease 2019 (COVID-19) Have Long-Term Persistent Symptoms and Functional Impairment Similar to Patients with Severe COVID-19: A Cautionary Tale During a Global Pandemic. Clin Infect Dis 2021 Aug 2;73(3):e826-e829

  Mayssam Nehme et all : Prevalence of Symptoms More Than Seven Months After Diagnosis of Symptomatic COVID-19 in an Outpatient Setting. Annals of Internal Medicine sept 21

  Petersen MS : Long COVID in the Faroe Islands: A Longitudinal Study … Clin Infect Dis. 2020 Nov 30

  Carfi A. : Persistent Symptoms in Patients After Acute COVID-19. JAMA. 2020 Aug 11;324(6):603-605.

  Miskowiak K W et coll : Cognitive impairments four months after COVID-19 hospital discharge: Pattern, severity and association with illness variables Eur Neuropsychopharmacol. 2021 May:46:39-48 Jaywant, A. et al. Frequency and profile of objective cognitive deficits in hospitalized patients recovering from COVI19. Neuropsychopharmacol. (2021)

  Dzifa Adjaye-Gbewonyo et coll : Long COVID in Adults: United States, 2022 NCHS Data Brief ■ No. 480 ■ September 2023

  Calcaianu G et al. Mid-term pulmonary sequelae after hospitalisation for COVID-19: the French SISCOVID cohort. Respiratory Medicine and Research (2022), Nov:82:100933.

  Tran VT et coll. Course of post COVID-19 disease symptoms over time in the ComPaRe long COVID prospective e-cohort. Nat Commun. 2022;13(1):1812.

  Panagiotis Giannos et coll : Gut dysbiosis and long COVID‐19: Feeling gutted. J Med Virol. 2022 Jul; 94(7): 2917–2918.

  HAS : Troubles psychiatriques et aspects psychologiques associés aux symptômes prolongés à la suite d’une Covid-19 de l’adulte. Fiche HAS du 6 avril 2023.

• Matthew S. Durstenfeld et coll ,Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults A Systematic Review and Meta-analysis JAMA Netw Open. 2022;5(10, October 12, 2022

  Shin Jie Yong : Persistent Brainstem Dysfunction in Long-COVID: A Hypothesis ACS Chem Neurosci 2021 Feb 17;12(4):573-580.

  Santé Publique France : Enquête « COVID long – Affection post-COVID-19, France métropolitaine », septembre-novembre 2022, premiers résultats. 21 Juin 2023

  Emily Harris : US Survey: About 7% of Adults, 1% of Children Have Had Long COVID. JAMA.October 4, 2023.

• Ferdenzi Cet coll : Recovery from COVID-19-related olfactory disorders and quality of life: insights from an observational online study. Chem Senses. 2021 Jun 07

  Stricker, R.B. and Fesler, M.C. :A Novel Plan to Deal with SARS-CoV-2 and COVID-19 Disease. Journal of Medical Virology, April 28. 2020

  APM News : Covid long: un risque cardiovasculaire augmenté de façon persistante. APM NEWS Mardi 08 février 2022 – 12:31

• Adeline Dugerdi et coll : Severe SARS-CoV-2 infection as a marker of undiagnosed cancer: a population-based study. Scientific Reports volume 13, Article number: 8729 (2023)

• Zhang B, et all : Risk of cytomegalovirus diseases among coronavirus disease survivors: A retrospective cohort study. J Med Virol. 2023 Sep;95(9):e29096.

MECANISMES

• Sabine Hazan et al : Lost microbes of COVID-19: Bifidobacterium, Faecalibacterium depletion and decreased microbiome diversity associated with SARS-CoV-2 infection severity BMJ Gastroenterology 28.4.2022
• Hannah E. Davis et col : Long COVID: major findings, mechanisms and recommendations Nature Reviews Microbiology volume 21, pages133–146 (2023)
  Daniel Chertow “SARS-CoV-2 infection and persistence throughout the human body and brain” Biological Science, Décembre 20,2021
• Jasimuddin Ahamed :Long Covid endotheliopathy: hypothesized mechanisms and potential therapeutic approaches” J Clin Invest. 2022 Aug 1;132(15)
• Jérôme Kervevan et coll : Divergent adaptive immune responses define two types of long COVID, Frontiers in Immunology, 20 juillet 2023
  Diane E Griffin “Why does viral RNA sometimes persist after recovery from acute infections?” PLoS Biol. 2022 Jun 1:20(6)
  Peluso MJ : “Evidence of recent Epstein Barr virus reactivation in individuals experiencing Long COVID” medRxiv 2022
• Eric Y Wang :“Diverse functional autoantibodies in patients with COVID 19” Nature. 2021 Jul;595
• Yeni Acosta-Ampudia “ Persistent Autoimmune Activation and Proinflammatory State in Post-Coronavirus disease 2019 Syndrome » J Infect Dis. 2022 Jan 25
• Iba T : Coagulopathy in COVID 19” J Thromb Haemost 2020 Sep;18:2103-2109
• Pellegrini Dario : Microthrombi as a major cause of cardiac injury in COVID 19, a pathologic study” Circulation 2021, 1031-1042
• Lee MH, Perl DP, Nair G, et al. Microvascular Injury in the Brains of Patients with Covid-19. N Engl J Med. 2021 Feb 4;384(5):481-483
• Guedj E et coll : F.-FDG brain PET hypometabolism in post-SARS-CoV-2 infection: substrat for persistent/delayed disorders. Eur J Nucl Med Mol Imaging . 2021 Feb;48(2):592-595.
• 
  Garth L. Nicolson et col : COVID-19 Coronavirus: Is Infection along with Mycoplasma or Other Bacteria Linked to Progression to a Lethal Outcome? International Journal of Clinical Medicine, 2020, 11, 282-302
• Lee MH, Perl DP, Steiner J, et coll. : Neurovascular injury with complement activation and inflammation in COVID-19. Brain, 2022
• Qin Liu et coll : Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome. Gut, March 2022 – Volume 71 – 3, 544-552
• John M. Arthur et coll : Development of ACE2 autoantibodies after SARS-CoV-2 infection. Plos one September 3, 2021
• Jeffrey E. Gold et coll : Investigation of Long COVID Prevalence and Its Relationship to Epstein-Barr Virus Reactivation. Pathogens 2021, 10(6), 763;
• William J. Murphy et col : A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination. N Engl J Med , January 27, 2022,386:394-396
• Van de Guchte M et coll : . Alternative stable states in the intestinal ecosystem: proof of concept in a rat model and a perspective of therapeutic implications. Microbiome. 2020;8(1):153

BILAN

• 
  Rostani M : D-dimer level in COVID-19 infection, a systematic review” Expert Review of Hematology 2020 13:1265-1275
• Zhang l : D-dimer on admission to predict in hospital mortality in patients with COVID-19” Journal of Thrombosis and Hemostasis, 2020, 18: 1324-1329
• Jon Klein et all : Distinguishing features of Long COVID identified through immune profiling. Nature 10 oct 23

TRAITEMENT 

• Ron Conte : A Study of a Successful Treatment for Long Covid (Longhaulers) . Research Gate 11july 2020
• Dimitri Jacques : Covid long : il faut sauver le soldat mitochondrie. Alternative Santé 11 mai 2021
  HAS Covid-19 : diagnostiquer et prendre en charge les adultes présentant des symptômes prolongés. Communiqué de presse- Mis en ligne le 12 févr. 2021
  A. d’Oro : COVID LONG, des stratégies thérapeutiques ciblées et efficaces, Partie 1 : l’hypercoagulabilité. La Nutrition Santé 28.8.23
• Di Filippo et coll : Could Vitamin D Supplementation Help in Long COVID? – J Clin Endocrinol Metab. April 13, 2023.
• Chakraborty, S. and Das, G. (2020) Secondary Infection by Anaerobic Bacteria Possibly Ensues a Battle for Oxygen in SARS-CoV-2 Infected Patients: Anaerobe-Targeting Antibiotics (Like Doxyclcine/Metronidazole) to Supplement Azithromycin in the Treatment of COVID19? OSF Preprints, April 10. (In Press) https://doi.org/10.31219/osf.io/s48fv
  
  
• Shani Zilberman-Itskovich, Shai Efrati : Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial Scientific Reports volume 12, Article number: 11252 (2022)
• De Flora S “Rationale for use of N-acetyl-cysteine in both prevention and adjuvant therapy of COVID 19” FASEB J. 2020
• Carlos A. Labarrere “Glutathione deficiency in the pathogenesis of SARS-CoV-2 infection and its effects upon the host immune response in severe COVID-19 disease” Front Microbiol 2022;13:979719
• Emily Harris : Exercise Programs Might Improve Long COVID JAMA.September 27, 2023. doi:10.1001/jama.2023.18739
  The Phosp-Covid Collaborative : The clinical characteristics with inflammation profiling of long covid and association with 1 year recovery following hospitalisation in the UK : a prospective observational study; Lancet Respir Med. 2022 ; 23 april 2022
• Brendan O’Kelly et coll : Safety and efficacy of low dose naltrexone in a long covid cohort; an interventional pre-post study Brain Behav Immun Health. 2022 Oct; 24: 100485.
• Hector Bonilla et coll : Low-Dose Naltrexone use for the management of post-acute sequelae of COVID-19. Pre print https://doi.org/10.1101/2023.06.08.23291102
• Brain Behav et coll : Safety and efficacy of low dose naltrexone in a long covid cohort Immun Health. 2022 Oct; 24: 100485.
• Claudia Vollbracht et coll : Feasibility of Vitamin C in the Treatment of Post Viral Fatigue with Focus on Long COVID, Based on a Systematic Review of IV Vitamin C on Fatigue. Nutrients. 2021 Apr; 13(4): 1154
• Fatma Yildirim et coll : Effect of high-dose intravenous vitamin C on prognosis in patients with SARS-CoV-2 pneumonia. Medicina Clinica 2021 May 11].
• R.C. Yüksel, et al. : Effects of high dose vitamin c on patient outcomes in ARDS patients admitted to intensive care with COVID-19; multi-center retrospective study. ICMx, 9 (2021), pp. 51
• B. Zhao, Y. Ling, et coll : . Beneficial aspects of high dose intravenous vitamin C on patients with COVID-19 pneumonia in severe condition: a retrospective case series study. Ann Palliat Med, 10 (2021), pp. 1599-1609
• Claudia Vollbrachtet et Karin Kraft : Oxidative Stress and Hyper-Inflammation as Major Drivers of Severe COVID-19 and Long COVID: Implications for the Benefit of High-Dose Intravenous Vitamin C. Front. Pharmacol., 29 April 2022, Volume 13 – 2022
• Hongjie Chen et all : Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomark Insights. 2018; 13: 1177271918785130.
• Sentosphère : Le loto des odeurs, la Route des épices, Topsent, sentosphere.com 

VACCINATION

• Frederikus Klok : Vaccine-induced immune thrombotic thrombocytopenia” Lancet Haematol. 2022 Jan;9(1)
• Mulu Woldegiorgis et coll : Long COVID in a highly vaccinated population infected during a SARS-CoV-2 Omicron wave – Australia, 2022. BMJ preprint aout 22
• Sophie Diexer et coll : Association between virus variants, vaccination, previous infections, and post-COVID-19 risk . International Journal of Infections Diseases Int J Infect Dis. 2023 Aug 25 : 136 : 14-21
• Kathy Katella: Why Vaccines May Be Helping Some With Long COVID. Research & Innovation APRIL 12, 2021
  Pascal Meylan : Covid long chez des individus infectés malgré le vaccin et effet du vaccin sur les symptômes. REVMED.2022.18.789.1378
• Viet-thi tran : Efficacy of first dose of covid-19 vaccine versus no vaccination on symptoms of patients with long covid: target trial emulation based on ComPaRee-cohort. BMJ feb 2023