Laurent Toubiana

Docteur en Physique, Chercheur à l’INSERM

Directeur de l’équipe SCEPID (Système Complexes et Epidémiologie)

Fondateur et directeur de plusieurs observatoires de santé publique et études observationnelles multicentriques

A  participé au développement de plateforme d’information santé comme le réseau Sentinelles, SIMS-REIN, CEMARA .

                                                                      

Formation 

• • Doctorat – Docteur en Astrophysique (CNRS URA 328 / CNES / IRAM-Grenade Espagne / Jet Propulsion Laboratory-USA) Université Paris XI, Orsay (1992)
  • EHESS « Ecole des Hautes Etudes en Sciences Sociales » : DEA démographie (1992)
  • DESS Informatique de la faculté d’Orsay (INRIA) – Université Paris XI, Orsay (1985)
  • HEC Paris « Ecole des Hautes Etudes Commerciales » : Formation en gestion d’entreprise, Jouy en Josas (2007)
  • Ingénieur diplômé : École Polytechnique de l’Université Paris-Sud (1985)

Expérience Professionnelle

• • INSERM UMRS 1142 LIMICS Laboratoire d’Informatique Médicale et d’Ingénierie des connaissances, Univ. Paris 6 (à partir de 2013)
  • Laboratoire UPRES EA 4472 « Namades ». Biostat. & Informatique Médicale – Necker – Université René Descartes Paris 5 Paris (2005-2012)
  • INSERM U707 (U444 – U263) « Epidémiologie, Systèmes d’Information, Modélisation » – OMS pour la surveillance électronique des maladies ; SCEPIDE « Syst. Complexe Epidémiologie» (1992-2005)
  • INSERM U113 « Etude fondamentale et clinique du système ostéoarticulaire » (1988-1992)
  • CNRS URA 328 – Observatoire de Meudon « Analyse spectrale spatiale PRONAOS » (CNES) ; IRAM (Institut de Radio Astronomie Millimétrique) ; Jet Propulsion Laboratory (États-Unis) (1986-1988)
  • THOMSON-CSF RCM : Radar et Contre Mesure ; INRIA Département des réseaux de télécommunication déterministes; SEMA-METRA Réseaux Télématiques Haut Débit (1985-1986)

PUBLICATIONS

• • Big data and smart health strategies: findings from the health information systems perspective.
    Toubiana L, Cuggia M. Yearb Med Inform. 2014 Aug 15;9(1):125-7. doi: 10.15265/IY-2014-0034.
    PMID: 25123731 Free PMC article. Review.
  • Reliability of Drug-Drug Interaction Measurement on Real-Word Data: The ReMIAMes Project.
    Duclos C, Griffon N, Daniel C, Bouzillé G, Delamarre D, Darmoni S, Toubiana L, Grosjean J.
    Stud Health Technol Inform. 2022 May 25;294:151-152. doi: 10.3233/SHTI220425.
    PMID: 35612045
  • Virtual surveillance of communicable diseases: a 20-year experience in France.
    Flahault A, Blanchon T, Dorléans Y, Toubiana L, Vibert JF, Valleron AJ.
    Stat Methods Med Res. 2006 Oct;15(5):413-21. doi: 10.1177/0962280206071639.
    PMID: 17089946 Review.
  • The geographical spread of influenza.
    Bonabeau E, Toubiana L, Flahault A.
    Proc Biol Sci. 1998 Dec 22;265(1413):2421-5. doi: 10.1098/rspb.1998.0593.
    PMID: 9921681 Free PMC article.
  • Some Innovative Approaches for Public Health and Epidemiology Informatics.
    Toubiana L, Griffon N.
    Yearb Med Inform. 2016 Nov 10;(1):247-250. doi: 10.15265/IY-2016-047.
    PMID: 27830258 Free PMC article.
  • CEMARA an information system for rare diseases.
    Landais P, Messiaen C, Rath A, Le Mignot L, Dufour E, Ben Said M, Jais JP, Toubiana L, Baujat G, Bourdon-Lanoy E, Gérard-Blanluet M, Bodemer C, Salomon R, Aymé S, Le Merrer M, Verloes A; CEMARA task force.
    Stud Health Technol Inform. 2010;160(Pt 1):481-5.
    PMID: 20841733
  • Sociodemographic and Clinical Characteristics of Vapers Using E-Cigarettes Exclusively: The French Vapoquid Study.
    Tran Luy M, Airagnes G, Matta J, Toubiana L, Allagbe I, Limosin F, Le Faou AL.
    Subst Use Misuse. 2021;56(13):2035-2043. doi: 10.1080/10826084.2021.1967987. Epub 2021 Sep 15.
    PMID: 34523386
  • Biotherapy and rheumatoid arthritis: a medico-economic evaluation from 2008 French Hospital Database.
    Maravic M, Baudens G, Sanchez JP, Flipo RM, Toubiana L, Landais P.
    Joint Bone Spine. 2012 Jan;79(1):96-7. doi: 10.1016/j.jbspin.2011.06.004. Epub 2011 Jul 30.
    PMID: 21803635 No abstract available.
  • Modelling, Simulation and Social Network Data: What’s New for Public Health and Epidemiology Informatics?
    Toubiana L, Griffon N.
    Yearb Med Inform. 2015 Aug 13;10(1):216-9. doi: 10.15265/IY-2015-031.
    PMID: 26293870 Free PMC article.
  • Building a Semantic Interoperability Framework for Care and Research in Fibromuscular Dysplasia.
    Jaulent MC, Assélé-Kama A, Savard S, Giavarini A, Touzé E, Jeunemaître X, Ugon A, Plouin PF, Toubiana L.
    Stud Health Technol Inform. 2015;216:217-21.
    PMID: 26262042
  • Incidence of all-cause adult community-acquired pneumonia in primary care settings in France.
    Partouche H, Lepoutre A, Vaure CBD, Poisson T, Toubiana L, Gilberg S.
    Med Mal Infect. 2018 Sep;48(6):389-395. doi: 10.1016/j.medmal.2018.02.012. Epub 2018 Apr 12.
    PMID: 29656842
  • Increased Collagen Turnover Is a Feature of Fibromuscular Dysplasia and Associated With Hypertrophic Radial Remodeling: A Pilot, Urine Proteomic Study.
    Latosinska A, Bruno RM, Pappaccogli M, Bacca A, Beauloye C, Boutouyrie P, Khettab H, Staessen JA, Taddei S, Toubiana L, Vikkula M, Mischak H, Persu A.
    Hypertension. 2022 Jan;79(1):93-103. doi: 10.1161/HYPERTENSIONAHA.121.18146. Epub 2021 Nov 17.
    PMID: 34788057
  • Enrichment of Rare Variants in Loeys-Dietz Syndrome Genes in Spontaneous Coronary Artery Dissection but Not in Severe Fibromuscular Dysplasia.
    Verstraeten A, Perik MHAM, Baranowska AA, Meester JAN, Van Den Heuvel L, Bastianen J, Kempers M, Krapels IPC, Maas A, Rideout A, Vandersteen A, Sobey G, Johnson D, Fransen E, Ghali N, Webb T, Al-Hussaini A, de Leeuw P, Delmotte P, Lopez-Sublet M, Pappaccogli M, Sprynger M, Toubiana L; European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI); Van Laer L, Van Dijk FS, Vikkula M, Samani NJ, Persu A, Adlam D, Loeys B; Collaborators of the European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI).
    Circulation. 2020 Sep 8;142(10):1021-1024. doi: 10.1161/CIRCULATIONAHA.120.045946. Epub 2020 Sep 8.
    PMID: 32897753 No abstract available.
  • Pregnancy-Related Complications in Patients With Fibromuscular Dysplasia: A Report From the European/International Fibromuscular Dysplasia Registry.
    Pappaccogli M, Prejbisz A, Ciurică S, Bruno RM, Aniszczuk-Hybiak A, Bracalente I, De Backer T, Debiève F, Delmotte P, Di Monaco S, Jarraya F, Gordin D, Kosiński P, Kroon AA, Maas AHEM, Marcon D, Minuz P, Montagud-Marrahi E, Pasquet A, Poch E, Rabbia F, Stergiou GS, Tikkanen I, Toubiana L, Vinck W, Warchoł-Celińska E, Van der Niepen P, de Leeuw P, Januszewicz A, Persu A; European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI) and the Working Group “Hypertension and the Kidney” of the ESH.
    Hypertension. 2020 Aug;76(2):545-553. doi: 10.1161/HYPERTENSIONAHA.120.15349. Epub 2020 Jul 8.
    PMID: 32639884
  • Prevalence and characteristics of renal artery fibromuscular dysplasia in hypertensive women below 50 years old.
    Di Monaco S, Lengelé JP, Heenaye S, Danse E, Hammer F, Lopez-Sublet M, Toubiana L, Rabbia F, Persu A.
    Eur J Clin Invest. 2019 Oct;49(10):e13166. doi: 10.1111/eci.13166. Epub 2019 Sep 19.
    PMID: 31454065
  • The European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI)-clinical phenotypes and their predictors based on a cohort of 1000 patients.
    Pappaccogli M, Di Monaco S, Warchoł-Celińska E, Lorthioir A, Amar L, Aparicio LS, Beauloye C, Bruno RM, Chenu P, de Leeuw P, De Backer T, Delmotte P, Dika Z, Gordin D, Heuten H, Iwashima Y, Krzesinski JM, Kroon AA, Mazzolai L, Poch E, Sarafidis P, Seinturier C, Spiering W, Toubiana L, Van der Niepen P, van Twist D, Visonà A, Wautrecht JC, Witowicz H, Xu J, Prejbisz A, Januszewicz A, Azizi M, Persu A; European/International FMD Registry and Initiative (FEIRI), and the Working Group ‘Hypertension and the Kidney’ of the European Society of Hypertension (ESH).
    Cardiovasc Res. 2021 Feb 22;117(3):950-959. doi: 10.1093/cvr/cvaa102.
    PMID: 32282921
  • MetaSurv: Web-Platform Generator for the Monitoring of Health Indicators and Interactive Geographical Information System.
    Toubiana L, Moreau S, Bonnard G.
    Stud Health Technol Inform. 2005;116:989-93.
    PMID: 16160387
  • [Fibromuscular dysplasia and hypertension : beyond renal arteries].
    Wuerzner G, Krieger C, Bouchardy J, Toubiana L, Delmotte P, Van der Niepen P, Déglise S, Qanadli S, Burnier M, Mazzolai L, Persu A.
    Rev Med Suisse. 2017 Sep 13;13(574):1580-1583.
    PMID: 28905547 French.
  • French cardiovascular mortality did not increase during 1996 European football championship.
    Toubiana L, Hanslik T, Letrilliart L.
    BMJ. 2001 May 26;322(7297):1306.
    PMID: 11403063 Free PMC article. No abstract available.
  • A « pivot » Model to set up Large Scale Rare Diseases Information Systems: Application to the Fibromuscular Dysplasia Registry.
    Toubiana L, Ugon A, Giavarini A, Riquier J, Charlet J, Jeunemaitre X, Plouin PF, Jaulent MC.
    Stud Health Technol Inform. 2015;210:887-91.
    PMID: 25991283
  • Suspected community-acquired pneumonia in an ambulatory setting (CAPA): a French prospective observational cohort study in general practice.
    Partouche H, Buffel du Vaure C, Personne V, Le Cossec C, Garcin C, Lorenzo A, Ghasarossian C, Landais P, Toubiana L, Gilberg S.
    NPJ Prim Care Respir Med. 2015 Mar 12;25:15010. doi: 10.1038/npjpcrm.2015.10.
    PMID: 25763466 Free PMC article.
  • ADVISE: First Results of a European Interoperative Information System Network Developed for the ADenoVirus Initiative Study in Epidemiology.
    Toubiana L, Riquier J, Duquesroix B.
    Stud Health Technol Inform. 2015;210:675-7.
    PMID: 25991236
  • Virus diversity in a winter epidemic of acute diarrhea in France.
    Chikhi-Brachet R, Bon F, Toubiana L, Pothier P, Nicolas JC, Flahault A, Kohli E.
    J Clin Microbiol. 2002 Nov;40(11):4266-72. doi: 10.1128/JCM.40.11.4266-4272.2002.
    PMID: 12409408 Free PMC article.
  • Venous thromboembolism prophylaxis in patients undergoing abdominal or pelvic surgery for cancer–a real-world, prospective, observational French study: PRéOBS.
    Samama CM, Boubli L, Coloby P, Debourdeau P, Gruel Y, Mariette C, Mottier D, Rischmann P, Toubiana L, Steib A.
    Thromb Res. 2014 Jun;133(6):985-92. doi: 10.1016/j.thromres.2013.10.038. Epub 2013 Nov 1.
    PMID: 24231117
  • Sentinelle traces of an epidemic of acute gastroenteritis in France.
    Flahault A, Garnerin P, Chauvin P, Farran N, Saidi Y, Diaz C, Toubiana L, Drucker J, Valleron AJ.
    Lancet. 1995 Jul 15;346(8968):162-3. doi: 10.1016/s0140-6736(95)91214-2.
    PMID: 7603234 No abstract available.
  • A Web-based GIS for health care decision-support.
    Jean-Baptiste R, Toubiana L, Le Mignot L, Ben Said M, Mugnier C, Le Bihan-Benjamin C, Jaïs JP, Landais P.
    AMIA Annu Symp Proc. 2005;2005:365-9.
    PMID: 16779063 Free PMC article.
  • SIGNe: A Geographic Information System on the Web for End-Stage Renal Disease.
    Richard JB, Toubiana L, le Mignot L, Ben Said M, Mugnier C, le Bihan-Benjamin C, Jaïs JP, Landais P.
    Stud Health Technol Inform. 2005;116:713-8.
    PMID: 16160342
  • Epidemic spread and bifurcation effects in two-dimensional network models with viral dynamics.
    Tuckwell HC, Toubiana L, Vibert JF.
    Phys Rev E Stat Nonlin Soft Matter Phys. 2001 Oct;64(4 Pt 1):041918. doi: 10.1103/PhysRevE.64.041918. Epub 2001 Sep 26.
    PMID: 11690063
  • A new approach for cleansing geographical dataset using Levenshtein distance, prior knowledge and contextual information.
    Ugon A, Nicolas T, Richard M, Guerin P, Chansard P, Demoor C, Toubiana L.
    Stud Health Technol Inform. 2015;210:227-9.
    PMID: 25991137
  • Enhancement of epidemic spread by noise and stochastic resonance in spatial network models with viral dynamics.
    Tuckwell HC, Toubiana L, Vibert JF.
    Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 2000 May;61(5 Pt B):5611-9. doi: 10.1103/physreve.61.5611.
    PMID: 11031615
  • Health Information Systems. Toward Evidence-based Health Information Systems?
    Toubiana L, Cuggia M; Section Editors for the IMIA Yearbook Section on Health Information Systems.
    Yearb Med Inform. 2013;8:114-6.
    PMID: 23974557
  • Regulation of plasma calcium and phosphate in calcitonin-infused rats.
    Lausson S, Tracqui P, Toubiana L, Milhaud G, Perault-Staub AM, Staub JF.
    Am J Physiol. 1990 Sep;259(3 Pt 1):E370-7. doi: 10.1152/ajpendo.1990.259.3.E370.
    PMID: 2399975
  • Dynamical modeling of viral spread in spatially distributed populations: stochastic origins of oscillations and density dependence.
    Tuckwell HC, Toubiana L.
    Biosystems. 2007 Sep-Oct;90(2):546-59. doi: 10.1016/j.biosystems.2006.12.006. Epub 2006 Dec 20.
    PMID: 17324498 Free PMC article.
  • Geographical information system for end-stage renal disease: SIGNe, an aid to public health decision making.
    Toubiana L, Richard JB, Landais P.
    Nephrol Dial Transplant. 2005 Feb;20(2):273-7. doi: 10.1093/ndt/gfh621.
    PMID: 15673688 No abstract available.
  • Log files analysis to assess the use and workload of a dynamic web server dedicated to end-stage renal disease.
    Ben Said M, Le Mignot L, Richard JB, Le Bihan C, Toubiana L, Jais JP, Landais P.
    Stud Health Technol Inform. 2006;124:277-82.
    PMID: 17108537
  • ICPCview: visualizing the International Classification of Primary Care.
    Lévy PP, Duché L, Darago L, Dorléans Y, Toubiana L, Vibert JF, Flahault A.
    Stud Health Technol Inform. 2005;116:623-8.
    PMID: 16160327
  • A space-time criterion for early detection of epidemics of influenza-like-illness.
    Toubiana L, Flahault A.
    Eur J Epidemiol. 1998 Jul;14(5):465-70. doi: 10.1023/a:1007481929237.
    PMID: 9744678
  • SITIE: a health care workstation integration architecture for epidemiologists.
    Toubiana L, Vibert JF, Garnerin P, Valleron AJ.
    Comput Biomed Res. 1995 Apr;28(2):100-15. doi: 10.1006/cbmr.1995.1008.
    PMID: 7656548